We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Levothyroxine and Liothyronine on Cirrhotic Cardiomyopathy in Rats.
- Authors
Jafari, Razieh Mohammad; Mohammed, Dlshad; Tavangar, Seyed Mohammad; Eftekhari, Golnar; Zeini, Maryam Shokrian; Khodadoostan, Arash; Dehpour, Ahmad Reza; Jazaeri, Farahnaz
- Abstract
In liver cirrhosis, there is low T3 syndrome associated with a decrease in total triiodothyronine (T3) and free T3 concentrations and cirrhotic cardiomyopathy (CCM) with chronotropic incompetence. Thus, we aimed to investigate the effects of eliminating T3 and thyroxine (T4) deficiencies on cardiac chronotropic dysfunction. Bile duct ligation (BDL) was used to induce cirrhosis in male Wistar rats. The chronotropic responses were studied through the Power Lab system in sham/saline, sham/T3T4, BDL/saline, and BDL/T3T4 groups. The serum T3 and T4, and T3 resin uptake (T3RU) levels were assessed. The atrial T3 receptor expression was investigated through a real-time polymerase chain reaction (Real-time PCR). The chronotropic responses were decreased in the BDL/saline group and raised in the BDL/T3T4 group. The serum T3 levels decreased in the BDL/saline group compared to sham group, but increased in the BDL/T3T4 group compared to the BDL/saline group. The serum T4 level increased in the BDL/saline and decreased in the BDL/T3T4 group. The serum T3RU level decreased in the BDL/saline and increased in the BDL/T3T4 group. The T3 receptor expression in atria increased in the BDL/saline group, nonetheless, it did not change in the BDL/T3T4 group compared to the sham/saline and the BDL/saline groups. T3T4 treatment did not increase the chronotropic response in the control group but the treatment improved the chronotropic hyporesponsiveness, and serum T4 and T3 RU abnormalities in cirrhosis, however, it is not related to the atrial T3 receptor expression.
- Subjects
TRIIODOTHYRONINE; CARDIOMYOPATHIES; POLYMERASE chain reaction; LEVOTHYROXINE; RATS
- Publication
Acta Medica Iranica, 2023, Vol 61, Issue 10, p607
- ISSN
0044-6025
- Publication type
Article