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- Title
The diagnostic value of <sup>18</sup>F-FDG PET/CT in identifying the causes of fever of unknown origin.
- Authors
Wan Zhu; Wenxia Cao; Xuting Zheng; Xuena Li; Yaming Li; E. Baiyi Chen; Jingping Zhang
- Abstract
Background This study investigated the clinical significance of 18F-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO). Methods Patients with a fever who received an 18F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test. Results Among the 89 included patients, 66 were diagnosed using 18F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of 18F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant. Conclusions 18F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.
- Subjects
C-reactive protein; COMPARATIVE studies; COMPUTED tomography; DEOXY sugars; ETIOLOGY of diseases; FEVER; INFECTION; INFLAMMATION; MEDICAL records; RADIOPHARMACEUTICALS; T-test (Statistics); POSITRON emission tomography; TUMORS; RETROSPECTIVE studies; DESCRIPTIVE statistics; ACQUISITION of data methodology
- Publication
Clinical Medicine, 2020, Vol 20, Issue 5, p449
- ISSN
1470-2118
- Publication type
Article
- DOI
10.7861/clinmed.2020-0268