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- Title
Selective retrograde transport of nipecotic acid, a GABA analog, labels a subpopulation of gerbil olivocochlear neurons.
- Authors
Ryan, Allen F.; Keithley, Elizabeth M.; Schwartz, Ilsa R.; Wang, Zhi-Xian
- Abstract
Perfusion of the gerbil cochlea with micromolar quantities of 3H-γ-aminobutyric acid (GABA) results in rapid, selective labeling of 50-60% of the olivocochlear (OC) efferent terminals on afferent dendrites beneath the inner hair cells, and all of the efferent terminals beneath the outer hair cells. In order to identify the neurons from which these GABA-accumulating terminals originate, the cell bodies were localized by using retrograde transport of 3H-nipecotic acid, a metabolically inert GABA analog. With survival times of 6-30 hours after cochlear injection, myelinated OC efferent fibers and cell bodies were well labeled, with the greatest number being labeled at 12-18 hours. All of the labeled neurons belonged to the medial OC system, and no lateral OC neurons were labeled. It is concluded that the GABA-accumulating endings in the gerbil cochlea arise from medial OC neurons, and therfore that medial OC efferent neurons in this species project to both inner and outer hair cell regions. © 1992 Wiley-Liss, Inc.
- Publication
Journal of Comparative Neurology, 1992, Vol 326, Issue 3, p337
- ISSN
0021-9967
- Publication type
Article
- DOI
10.1002/cne.903260303