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- Title
PHENOLIC CONTENT, ANTIOXIDANT ACTIVITY AND EFFECT ON COLLAGEN SYNTHESIS OF A TRADITIONAL WOUND HEALING POLYHERBAL FORMULA.
- Authors
Alexandru, Valentina; Gaspar, Alexandra; Savin, Simona; Toma, Agnes; Tatia, Rodica; Gille, Elvira
- Abstract
The aim of this study was to investigate the ethanol extracts of four medicinal plants, Achillea millefolium L., Hyssopus officinalis L., Equisetum arvense L. and Echinacea purpurea L. and their polyherbal formula, used in traditional medicine for wound healing. The study analyzed their total phenolics content using Folin-Ciocalteu method and identified the main constituents by HPLC. Their antioxidant activity was evaluated by DPPH and ABTS assays and the formula's capacity to enhance collagen synthesis in L929 fibroblast cell culture was determined by Sircol assay. The results showed that the polyherbal extract had phenolic constituents with pharmacological properties: chlorogenic acid, caffeic acid, luteolin and apigenin. It was showed that the polyherbal formula presented higher antioxidant activity than plant extracts and induced a stimulation of collagen synthesis by fibroblasts, which could contribute to wound strength. In conclusion, the proposed polyherbal formula demonstrated high potential as therapeutic agent in wound healing.
- Subjects
PLANT extracts; COMMON yarrow; HYSSOPUS officinalis; EQUISETUM; ECHINACEA (Plants); COLLAGEN; ETHANOL; PHENOLS
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2015, Vol 25, Issue 1, p41
- ISSN
1584-2363
- Publication type
Article