We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Study of Serum and Ascitic Fluid Lipopolysaccharide Binding Protein as Potential Markers of Infection in Spontaneous Bacterial Peritonitis.
- Authors
El-Antouny, Neveen George; Al-Sayed, Ahmed Abdul Naby; Mohammed, Ahmed Abdul-Saboor; elkhalik, Heba Shafeak Abd
- Abstract
Background: Hemodynamic instability in cirrhotic individuals and the onset of bacterial infection are both linked to elevated levels of Lipopolysaccharide binding protein (LBP). Objective: The aim of the current work was to evaluate the significance of lipopolysaccharide binding protein (LBP) level in serum and ascitic fluid in spontaneous bacterial peritonitis (SBP) patients as a marker for infection. Patients and Methods:A total of 112 patients were enrolled in this case control study and were split into two categories: Group (A):consisted of 56 individuals with chronic liver disease (CLD) having ascites exacerbated by spontaneous bacterial peritonitis (SBP) through clinical and laboratory examinations. Group (B): consisted of 56 individuals with chronic liver disease (CLD) and ascites who had no detectable infection based on clinical and laboratory tests. Results: In group A; significant positive correlations were found between serum LBP, HB, and total protein. Also, a negative remarkable correlation between serum LBP, INR, PTT, PT, serum creatinine, direct bilirubin, total bilirubin, PLT, and ascitic fluid LBP. In group (B);significant positive correlations were found between serum LBP, AST, and TLC. Also, a negative remarkable correlation between serum LBP, PTT, serum urea, serum creatinine, and total bilirubin. Conclusion: It could be concluded that serum LBP demonstrated a highly significant difference between the two groups with a substantial difference as regard the diagnosis of spontaneous bacterial peritonitis, both in terms of sensitivity and specificity. Serum LBP may be considered as a diagnostic tool for SBP in cirrhotic patients with ascites.
- Subjects
ASCITIC fluids; CARRIER proteins; LIPOPOLYSACCHARIDES; PERITONITIS; BACTERIAL diseases; INTRA-abdominal infections
- Publication
Egyptian Journal of Hospital Medicine, 2023, Vol 90, Issue 1, p1597
- ISSN
1687-2002
- Publication type
Article
- DOI
10.21608/ejhm.2023.283669