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- Title
NSAIDs and apoptosis.
- Authors
Jana, N. R.
- Abstract
Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with decreased incidence of cancer of the colon and other gastrointestinal organs. The chemopreventive properties of NSAIDs are due to their ability to induce apoptosis. Both COX-2-dependent and COX-2-independent mechanisms are involved in NSAIDs-induced neoplastic growth. This article reviews the recent literature that has revealed various important mechanisms of NSAIDs-induced apoptosis.
- Subjects
ASPIRIN; NONSTEROIDAL anti-inflammatory agents; APOPTOSIS; COLON cancer; PHARMACODYNAMICS
- Publication
Cellular & Molecular Life Sciences, 2008, Vol 65, Issue 9, p1295
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-008-7511-x