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- Title
Protein kinase B: signalling roles and therapeutic targeting.
- Authors
Sale, E. M.; Sale, G. J.
- Abstract
The serine/threonine kinase, protein kinase B (PKB, also known as Akt), is activated by a wide array of growth factors and insulin. PKB is a central player in the regulation of metabolism, apoptosis, transcription and the cell-cycle. PKB exists as three isoforms (alpha, beta and gamma) that may have unique as well as common functions within the cell. Deregulation of PKB is associated with several human diseases, including cancer, diabetes and schizophrenia. These findings underscore the medical relevance of the PKB pathway and make PKB an attractive drug target for the treatment of diseases that exhibit abnormal PKB signalling.
- Subjects
SERINE; PROTEIN kinases; INSULIN; GROWTH factors; APOPTOSIS; CELL cycle
- Publication
Cellular & Molecular Life Sciences, 2008, Vol 65, Issue 1, p113
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-007-7274-9