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- Title
Efficacy of AS04-Adjuvanted Vaccine Against Human Papillomavirus (HPV) Types 16 and 18 in Clearing Incident HPV Infections: Pooled Analysis of Data From the Costa Rica Vaccine Trial and the PATRICIA Study.
- Authors
Tota, Joseph E; Struyf, Frank; Hildesheim, Allan; Gonzalez, Paula; Ryser, Martin; Herrero, Rolando; Schussler, John; Karkada, Naveen; Rodriguez, Ana Cecilia; Folschweiller, Nicolas; Porras, Carolina; Schiffman, Mark; Schiller, John T; Quint, Wim; Kreimer, Aimée R; Lehtinen, Matti; Wheeler, Cosette M; Sampson, Joshua N
- Abstract
Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 (AS04-HPV-16/18) vaccine provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher irrespective of type, among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection. Although AS04-HPV-16/18 vaccination does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. We pooled data from 2 large-scale randomized controlled trials to evaluate efficacy of the AS04-HPV-16/18 vaccine against clearance of nontargeted incident infections. Results of our analysis do not suggest an effect in expediting clearance of incident infections.
- Subjects
COSTA Rica; HUMAN papillomavirus vaccines; VACCINE trials; VACCINE effectiveness; CERVICAL intraepithelial neoplasia; DATA analysis; PAPILLOMAVIRUSES; RESEARCH; RESEARCH methodology; IMMUNOMODULATORS; EVALUATION research; TREATMENT effectiveness; COMPARATIVE studies; PAPILLOMAVIRUS diseases; BLIND experiment; RESEARCH funding; CERVIX uteri tumors
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 9, p1576
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa561