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Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors.
Published in:
Journal of Extracellular Vesicles, 2021, v. 10, n. 13, p. 1, doi. 10.1002/jev2.12165
By:
- Flores‐Bellver, Miguel;
- Mighty, Jason;
- Aparicio‐Domingo, Silvia;
- Li, Kang V.;
- Shi, Cui;
- Zhou, Jing;
- Cobb, Hannah;
- McGrath, Patrick;
- Michelis, German;
- Lenhart, Patricia;
- Bilousova, Ganna;
- Heissel, Søren;
- Rudy, Michael J.;
- Coughlan, Christina;
- Goodspeed, Andrew E.;
- Becerra, S. Patricia;
- Redenti, Stephen;
- Canto‐Soler, M. Valeria
Publication type:
Article
Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?
Published in:
Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.718426
By:
- Ahmed, Md. Mahiuddin;
- Johnson, Noah R.;
- Boyd, Timothy D.;
- Coughlan, Christina;
- Chial, Heidi J.;
- Potter, Huntington
Publication type:
Article
The immune cytokine granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is an effective treatment for both Alzheimer's disease and the viral diseases caused by West Nile Virus and SARS‐CoV‐2 infection, indicating that inflammation and viral infection may be partners and therapeutic co‐targets in many brain disorders
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080184
By:
- Potter, Huntington;
- Boyd, Timothy D.;
- Woodcock, Jonathan H;
- Sillau, Stefan H;
- Ahmed, Md. Mahiuddin;
- Wang, Athena Ching‐Jung;
- Chial, Heidi J;
- Coughlan, Christina M;
- Kendall, Lon V.;
- Bosco‐Lauth, Angela;
- Markham, Neil;
- Stonedahl, Sarah;
- Fong, Derek;
- Clarke, Penny;
- Tyler, Kenneth L.
Publication type:
Article
Granulocyte‐Macrophage Colony‐Stimulating Factor Reduces Two Major Pathological Hallmarks of Alzheimer's Disease and Astrogliosis in the TgF344‐AD Rat Model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067785
By:
- Ahmed, Md. Mahiuddin;
- Wang, Athena Ching‐Jung;
- Boyd, Timothy D.;
- Solano, D. Adriana;
- Vielle, Anne;
- Markham, Neil;
- Coughlan, Christina M;
- Chial, Heidi J;
- Vergara, M. Natalia;
- Potter, Huntington
Publication type:
Article
Inflammation and innate immune system activation in neurodegeneration, Down syndrome, aging, and infection: Therapeutic target or partner?
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.056681
By:
- Potter, Huntington;
- Boyd, Timothy D.;
- Ahmed, Md. Mahiuddin;
- Kendall, Lon V.;
- Sillau, Stefan H;
- Coughlan, Christina M;
- Clarke, Penny;
- Stonedahl, Sarah;
- Chial, Heidi J
Publication type:
Article
Identification of small molecule drugs that target apolipoprotein E4‐catalyzed amyloid‐β fibrillization: A new therapeutic approach to Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.054678
By:
- Johnson, Noah R;
- Wang, Athena Ching‐Jung;
- Coughlan, Christina M;
- Sillau, Stefan H;
- Lucero, Esteban M;
- Viltz, Lisa;
- Markham, Neil;
- Allen, Cody;
- Dhanasekaran, A. Ranjitha;
- Chial, Heidi J;
- Potter, Huntington
Publication type:
Article
Increased Plasma brain‐derived neurotrophic factor (BDNF) as a Biomarker for Differentiating Mild Cognitive Impairment from Cognitive Healthy: A case‐control study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058648
By:
- Ng, Ted Kheng Siang;
- Coughlan, Christina M;
- Heyn, Patricia C;
- Tagawa, Alex;
- Carollo, James;
- Kua, Ee‐Heok;
- Mahendran, Rathi
Publication type:
Article
Granulocyte‐macrophage colony‐stimulating factor reverses Alzheimer's disease pathology in the tgf344‐AD rat model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.056289
By:
- Ahmed, Md. Mahiuddin;
- Wang, Athena Ching‐Jung;
- Boyd, Timothy D.;
- Solano, D. Adriana;
- Vielle, Anne;
- Markham, Neil;
- Coughlan, Christina M;
- Chial, Heidi J;
- Vergara, M. Natalia;
- Potter, Huntington
Publication type:
Article
Small molecule inhibitors of apolipoprotein E4‐catalyzed amyloid‐β fibrillization as novel therapeutics for Alzheimer's disease: Development of new models and analysis methods/screening studies/platforms.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043353
By:
- Johnson, Noah R.;
- Wang, Athena Ching‐Jung;
- Coughlan, Christina M.;
- Lucero, Esteban M.;
- Viltz, Lisa;
- Allen, Cody;
- Markham, Neil;
- Chial, Heidi J.;
- Potter, Huntington
Publication type:
Article
FOLATE PREVENTS THE DETRIMENTAL EFFECTS OF OLIGOMERIC Aβ ON INSULIN RECEPTOR LOCALIZATION AND FUNCTION AND LONG-TERM POTENTIATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P989, doi. 10.1016/j.jalz.2017.06.1352
By:
- Jung Wang, Athena Ching;
- Freund, Ron;
- Coughlan, Christina M.;
- Lucero, Esteban M.;
- DellAcqua, Mark;
- Potter, Huntington
Publication type:
Article
ABNORMAL CHROMOSOME COPY NUMBER AND ASSOCIATED NEURONAL CELL DEATH IN FRONTOTEMPORAL LOBAR DEGENERATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P661, doi. 10.1016/j.jalz.2017.06.790
By:
- Caneus, Julbert;
- Granic, Antoneta;
- Rademakers, Rosa;
- Dickson, Dennis W.;
- Coughlan, Christina M.;
- Chial, Heidi J.;
- Potter, Huntington
Publication type:
Article
SCREENING FOR INHIBITORS OF APOE4-CATALYZED Aβ OLIGOMER/FILAMENT FORMATION: A NOVEL APPROACH TO ALZHEIMER’S DISEASE DRUG DISCOVERY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P662, doi. 10.1016/j.jalz.2017.06.793
By:
- Coughlan, Christina M.;
- Wang, Athena;
- Viltz, Lisa;
- Chial, Heidi J.;
- Potter, Huntington
Publication type:
Article
Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study.
Published in:
Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.748015
By:
- Ng, Ted Kheng Siang;
- Heyn, Patricia C.;
- Tagawa, Alex;
- Coughlan, Christina;
- Carollo, James J.
Publication type:
Article
Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis.
Published in:
2018
By:
- Martin-Medina, Aina;
- Lehmann, Mareike;
- Burgy, Olivier;
- Hermann, Sarah;
- Baarsma, Hoeke A;
- Wagner, Darcy E;
- De Santis, Martina M;
- Ciolek, Florian;
- Hofer, Thomas P;
- Frankenberger, Marion;
- Aichler, Michaela;
- Lindner, Michael;
- Gesierich, Wolfgang;
- Guenther, Andreas;
- Walch, Axel;
- Coughlan, Christina;
- Wolters, Paul;
- Lee, Joyce S;
- Behr, Jürgen;
- Königshoff, Melanie
Publication type:
journal article
Obese adipose tissue extracellular vesicles inhibit recovery from dextran sulphate sodium (DSS)‐induced colitis.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5418
By:
- Delgado‐Deida, Yaritza;
- Coughlan, Christina;
- Theiss, Arianne
Publication type:
Article
Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer’s disease.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021, v. 7, n. 1, p. 1, doi. 10.1002/trc2.12158
By:
- Potter, Huntington;
- Woodcock, Jonathan H.;
- Boyd, Timothy D.;
- Coughlan, Christina M.;
- O’Shaughnessy, John R.;
- Borges, Manuel T.;
- Thaker, Ashesh A.;
- Raj, Balaibail A.;
- Adamszuk, Katarzyna;
- Scott, David;
- Adame, Vanesa;
- Anton, Paige;
- Chial, Heidi J.;
- Gray, Helen;
- Daniels, Joseph;
- Stocker, Michelle E.;
- Sillau, Stefan H.
Publication type:
Article
Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles.
Published in:
Biomedicines, 2022, v. 10, n. 11, p. 2718, doi. 10.3390/biomedicines10112718
By:
- Zhou, Wenbo;
- Lovasz, Daniel;
- Zizzo, Zoë;
- He, Qianbin;
- Coughlan, Christina;
- Kowalski, Robert G.;
- KennedyI, Peter G. E.;
- Graner, Arin N.;
- Lillehei, Kevin O.;
- Ormond, D. Ryan;
- Youssef, A. Samy;
- Graner, Michael W.;
- Yu, Xiaoli
Publication type:
Article
Palliative Care and Parkinson's Disease: Caregiver Perspectives.
Published in:
Journal of Palliative Medicine, 2017, v. 20, n. 9, p. 930, doi. 10.1089/jpm.2016.0325
By:
- Boersma, Isabel;
- Jones, Jacqueline;
- Coughlan, Christina;
- Carter, Julie;
- Bekelman, David;
- Miyasaki, Janis;
- Kutner, Jean;
- Kluger, Benzi
Publication type:
Article
Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer's disease cognition.
Published in:
Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01020-9
By:
- Johnson, Noah R.;
- Wang, Athena C.-J.;
- Coughlan, Christina;
- Sillau, Stefan;
- Lucero, Esteban;
- Viltz, Lisa;
- Markham, Neil;
- Allen, Cody;
- Dhanasekaran, A. Ranjitha;
- Chial, Heidi J.;
- Potter, Huntington
Publication type:
Article
Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice.
Published in:
Parkinson's Disease (20420080), 2015, v. 2015, p. 1, doi. 10.1155/2015/812532
By:
- Coughlan, Christina;
- Walker, Douglas I.;
- Lohr, Kelly M.;
- Richardson, Jason R.;
- Saba, Laura M.;
- Caudle, W. Michael;
- Fritz, Kristofer S.;
- Roede, James R.
Publication type:
Article
Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk.
Published in:
Journal of Infectious Diseases, 2023, v. 227, n. 8, p. 993, doi. 10.1093/infdis/jiac405
By:
- Bubak, Andrew N;
- Coughlan, Christina;
- Posey, Janelle;
- Saviola, Anthony J;
- Niemeyer, Christy S;
- Lewis, Serena W R;
- Lopez, Sara Bustos;
- Solano, Adriana;
- Tyring, Stephen K;
- Delaney, Cassidy;
- Neeves, Keith B;
- Mahalingam, Ravi;
- Hansen, Kirk C;
- Nagel, Maria A
Publication type:
Article
Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells.
Published in:
2021
By:
- Bubak, Andrew N;
- Beseler, Cheryl;
- Como, Christina N;
- Coughlan, Christina M;
- Johnson, Noah R;
- Hassell, James E;
- Burnet, Anna M;
- Mescher, Teresa;
- Schmid, D Scott;
- Coleman, Colin;
- Mahalingam, Ravi;
- Cohrs, Randall J;
- Boyd, Timothy D;
- Potter, Huntington;
- Shilleh, Ali H;
- Russ, Holger A;
- Nagel, Maria A
Publication type:
journal article
Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment.
Published in:
Journal of Infectious Diseases, 2020, v. 221, n. 7, p. 1088, doi. 10.1093/infdis/jiz560
By:
- Bubak, Andrew N;
- Como, Christina N;
- Coughlan, Christina M;
- Johnson, Noah R;
- Hassell, James E;
- Mescher, Teresa;
- Niemeyer, Christy S;
- Mahalingam, Ravi;
- Cohrs, Randall J;
- Boyd, Timothy D;
- Potter, Huntington;
- Russ, Holger A;
- Nagel, Maria A
Publication type:
Article
Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment.
Published in:
2020
By:
- Bubak, Andrew N;
- Como, Christina N;
- Coughlan, Christina M;
- Johnson, Noah R;
- Hassell, James E;
- Mescher, Teresa;
- Niemeyer, Christy S;
- Mahalingam, Ravi;
- Cohrs, Randall J;
- Boyd, Timothy D;
- Potter, Huntington;
- Russ, Holger A;
- Nagel, Maria A
Publication type:
journal article
Specific Binding of Alzheimer's Aβ Peptides to Extracellular Vesicles.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 7, p. 3703, doi. 10.3390/ijms25073703
By:
- Coughlan, Christina;
- Lindenberger, Jared;
- Jacot, Jeffrey G.;
- Johnson, Noah R.;
- Anton, Paige;
- Bevers, Shaun;
- Welty, Robb;
- Graner, Michael W.;
- Potter, Huntington
Publication type:
Article
Biomarkers of Neurodegeneration and Alzheimer's Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study.
Published in:
Endocrines, 2024, v. 5, n. 2, p. 197, doi. 10.3390/endocrines5020014
By:
- Shapiro, Allison L. B.;
- Coughlan, Christina;
- Bettcher, Brianne M.;
- Pauley, Meghan E.;
- Kim, Jeongchul;
- Bjornstad, Petter;
- Rajic, Benjamin;
- Truong, Jennifer;
- Bell, Christopher;
- Choi, Ye Ji;
- Walker, Keenan A.;
- Potter, Huntington;
- Liese, Angela D.;
- Dabelea, Dana;
- Whitlow, Christopher T.
Publication type:
Article
Plasma neurofilament light chain concentrations are elevated in youth‐onset type 2 diabetes and associated with neuropathy.
Published in:
Journal of the Peripheral Nervous System, 2023, v. 28, n. 3, p. 460, doi. 10.1111/jns.12575
By:
- Fridman, Vera;
- Sillau, Stefan;
- Ritchie, Alanna;
- Bockhorst, Jacob;
- Coughlan, Christina;
- Araya, Paula;
- Espinosa, Joaquin M.;
- Smith, Keith;
- Lange, Ethan M.;
- Lange, Leslie A.;
- Ghormli, Laure El;
- Drews, Kimberly L.;
- Zeitler, Philip;
- Reusch, Jane E. B.
Publication type:
Article
The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.
Published in:
PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0176307
By:
- Aivazidis, Stefanos;
- Coughlan, Christina M.;
- Rauniyar, Abhishek K.;
- Jiang, Hua;
- Liggett, L. Alexander;
- Maclean, Kenneth N.;
- Roede, James R.
Publication type:
Article

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