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- Title
Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
- Authors
Crawford, Katharine H D; Dingens, Adam S; Eguia, Rachel; Wolf, Caitlin R; Wilcox, Naomi; Logue, Jennifer K; Shuey, Kiel; Casto, Amanda M; Fiala, Brooke; Wrenn, Samuel; Pettie, Deleah; King, Neil P; Greninger, Alexander L; Chu, Helen Y; Bloom, Jesse D
- Abstract
Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral spike protein. In this study, we quantified how levels of these antibodies change in the months after SARS-CoV-2 infection by examining longitudinal samples collected approximately 30-152 days after symptom onset from a prospective cohort of 32 recovered individuals with asymptomatic, mild, or moderate-severe disease. Neutralizing antibody titers declined an average of about 4-fold from 1 to 4 months after symptom onset. This decline in neutralizing antibody titers was accompanied by a decline in total antibodies capable of binding the viral spike protein or its receptor-binding domain. Importantly, our data are consistent with the expected early immune response to viral infection, where an initial peak in antibody levels is followed by a decline to a lower plateau. Additional studies of long-lived B cells and antibody titers over longer time frames are necessary to determine the durability of immunity to SARS-CoV-2.
- Subjects
COVID-19; ANTIBODY titer; VIRAL proteins; VIRUS diseases; PROTEIN domains
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 2, p197
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1093/infdis/jiaa618