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- Title
Electro-acupuncture for irritable bowel syndrome patients: study protocol for a single-blinded randomized sham-controlled clinical trial.
- Authors
Zhong, Linda L. D.; Lam, Tsz Fung; Yang, Wei; Zheng, Ya; Lyu, Zipan; Bian, Zhaoxiang
- Abstract
<bold>Background: </bold>Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders in clinical practice. IBS diagnosis is based on symptoms defined by abdominal pain or discomfort associated with defecation or changes in bowel habits. Gut-brain interaction caused by stress or depressive emotion is one of the essential pathologies. Acupuncture has been used for the treatment of internal medicine, including digestive disorders and depressive disorders in Chinese medicine. This study aims to determine whether electro-acupuncture could have significant benefits than sham acupuncture for IBS.<bold>Methods/design: </bold>This is a single-blinded randomized sham-controlled clinical trial with two arms. A total of 120 IBS patients will be recruited. After a 2-week run-in period, eligible subjects will be randomly assigned to one of two arms, acupuncture (AC) arm and sham acupuncture (SAC) arm. Each eligible subject will go through a 2-week run-in-period, 6-week treatment period, and 6-week follow-up period. Five visits in total were scheduled for each subject in week 0, week 2, week 5, week 8, and week 14. The outcomes would be measured with (1) IBS-SSS, (2) Hamilton Depression Rating Scale (HAMD-17), (3) Clinical Global Impression-Severity (CGI-S), (4) Self-Rating Depression Scale (SDS), and (5) IBS Quality of Life (IBS-QoL).<bold>Discussion: </bold>The study will compare electro-acupuncture with sham acupuncture to explore the feasibility of electro-acupuncture in improving IBS symptoms.<bold>Trial Registration: </bold>ClinicalTrials.gov NCT04387383 . Registered on 13 May 2020.
- Subjects
IRRITABLE colon; CLINICAL trials; RESEARCH protocols; HAMILTON Depression Inventory; DIAGNOSIS; DEFECATION; IRRITABLE colon diagnosis; IRRITABLE colon treatment; ACUPUNCTURE; TREATMENT effectiveness; RANDOMIZED controlled trials; QUALITY of life; RESEARCH funding; ABDOMINAL pain
- Publication
Trials, 2021, Vol 22, Issue 1, p1
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-021-05563-4