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- Title
Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production.
- Authors
Dan-Feng Fan; Hui-Jun Hu; Xue-Jun Sun; Xiang-En Meng; Yu Zhang; Shu-Yi Pan
- Abstract
It has been known that the pathophysiology of carbon monoxide (CO) poisoning is related to hypoxia, the increased production of reactive oxygen species (ROS) and oxidative stress. Studies have shown that the novel, safe and effective free radical scavenger, hydrogen, has neuroprotective effects in both acute CO poisoning and delayed neuropsychological sequeconlae in CO poisoning. Orally administered lactulose, which may be used by some intestinal bacteria as a food source to produce endogenous hydrogen, can ameliorate oxidative stress. Based on the available findings, we hypothesize that oral administration of lactulose may be a novel therapy for acute CO poisoning via increasing intestinal hydrogen production.
- Subjects
LACTULOSE; CARBON monoxide; REACTIVE oxygen species; OXIDATIVE stress; ENDOGENOUS hydrogen sulfide; NEUROPROTECTIVE agents; HYDROGEN
- Publication
Undersea & Hyperbaric Medicine, 2016, Vol 43, Issue 1, p45
- ISSN
1066-2936
- Publication type
Article