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- Title
Effect of FK 506 on spontaneous diabetes in BB rats.
- Authors
Murase, Noriko; Lieberman, Irving; Nalesnik, Michael A.; Mintz, Daniel H.; Todo, Satoru; Drash, Allan L.; Starzl, Thomas E.; Murase, N; Lieberman, I; Nalesnik, M A; Mintz, D H; Todo, S; Drash, A L; Starzl, T E
- Abstract
From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, approximately 75% of the rats that were diabetes free at 120 days remained so.
- Publication
Diabetes, 1990, Vol 39, Issue 12, p1584
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.39.12.1584