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- Title
Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia.
- Authors
Wen-Sheng Qu; Yi-Hui Wang; Jun-Fang Ma; Dai-Shi Tian; Qiang Zhang; Deng-Ji Pan; Zhi-Yuan Yu; Min-Jie Xie; Jian-Ping Wang; Wei Wang
- Abstract
Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regulated in activated astrocytes around ischemic infarct. Furthermore, under ischemic conditions either in vitro or in vivo, Gal-1 was found to inhibit the proliferation of astrocytes in a dose-dependent manner, attenuate astrogliosis and down-regulate the astrogliosis associated expression of nitric oxide synthase and interleukin-1β after the ischemia. All these changes were blocked by lactose, suggesting a lectin dependent manner of Gal-1's function. Moreover, 7-day Gal-1 treatment reduced apoptosis of neurons, decreased brain infarction volume and improved neurological function induced by the ischemia. Together, these findings indicate that through reducing astrogliosis related damages, Gal-1 is a potential therapeutical target for attenuating neuronal damage and promoting recovery of brain ischemia.
- Subjects
CEREBRAL ischemia; NERVOUS system injuries; ASTROCYTES; NITRIC oxide; INTERLEUKIN-1; LACTOSE; LECTINS; LABORATORY rats; THERAPEUTICS
- Publication
Journal of Neurochemistry, 2011, Vol 116, Issue 2, p217
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.2010.07095.x