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- Title
Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism.
- Authors
Jong-So Kim; Coon, Steven L.; Weller, Joan L.; Blackshaw, Seth; Rath, Martin F.; Møller, Morten; Klein, David C.
- Abstract
Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.
- Subjects
PINEAL gland; ENDOCRINE glands; DROSOPHILA; RETINA; RNA splicing; GENETIC regulation; LABORATORY rats; PROTEINS
- Publication
Journal of Neurochemistry, 2009, Vol 110, Issue 2, p756
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.2009.06184.x