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- Title
Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy.
- Authors
Belen, Burcu Fatma; Gürsel, Türkiz; Akyürek, Nalan; Albayrak, Meryem; Kaya, Zühre; Koçak, Ülker
- Abstract
Myelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms. Mutations in the thiopurine S-methyltransferase (TPMT) gene causing excessive myelosuppression during 6-mercaptopurine (MP) therapy may cause excessive bone marrow toxicity. We report the case of a 15-year-old girl with T-ALL who developed severe pancytopenia during consolidation and maintenance therapy despite reduction of the dose of MP to 5% of the standard dose. Prednisolone therapy produced a remarkable but transient bone marrow recovery. Analysis of common TPMT polymorphisms revealed TPMT *3A/*3C.
- Subjects
THERAPEUTIC use of glucocorticoids; LYMPHOBLASTIC leukemia diagnosis; PREDNISOLONE; ANEMIA; BONE marrow; CANCER chemotherapy; GENETIC polymorphisms; MEDIASTINUM diseases; REGENERATION (Biology); THROMBOCYTOPENIA; TRANSFERASES; GENETIC carriers; LEUKOCYTE count; ADOLESCENCE; THERAPEUTICS
- Publication
Turkish Journal of Hematology, 2014, Vol 31, Issue 4, p399
- ISSN
1300-7777
- Publication type
Article
- DOI
10.4274/tjh.2013.0082