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- Title
The Association Between HLA Class II Alleles and the Occurrence of Factor VIII Inhibitor in Thai Patients with Hemophilia A.
- Authors
Nathalang, Oytip; Sriwanitchrak, Pramote; Sasanakul, Werasak; Chuansumrit, Ampaiwan
- Abstract
Objective: This study aimed to investigate the association between HLA class II alleles and the occurrence of FVHI inhibitor in Thai hemophilia A patients. Material and Methods: The distribution of HLA-DRB1 alleles and DQB1 alleles in 57 Thai hemophilia A patients and 36 blood donors as controls was determined using the PCR sequence-specific primer (PCR-SSP) method, and the association between the occurrence of factor VIII (FVIII) inhibitor and the presence of certain HLA class II alleles was investigated. Results: The frequency of HLA-DRB1*15 was higher in the hemophilia A patients with and without FVIII inhibitor, whereas that of DRB1H4, DRB1*O7, and DQB1*O2 was lower in the hemophilia A patients with FVIII inhibitor, as compared to controls. Interestingly, only the frequency of DRB1*15 was significantly higher in the patients with inhibitor than in the controls (P = 0.021). Moreover, the frequency of DRB1*15 in the patients with inhibitor was higher than in those without inhibitor (P = 0.198). Conclusion: The study's findings show that the DRB1*15 allele might have contributed to the occurrence of inhibitor in the Thai hemophilia A patients; however, additional research using larger samples and high-resolution DRB1 typing is warranted.
- Subjects
THAILAND; HEMOPHILIA; ALLELES; BLOOD coagulation factors; CHI-squared test; CONFIDENCE intervals; EPIDEMIOLOGY; FISHER exact test; POLYMERASE chain reaction; RESEARCH funding; STATISTICS; HLA-B27 antigen; DATA analysis; DESCRIPTIVE statistics; GENETICS
- Publication
Turkish Journal of Hematology, 2012, Vol 29, Issue 1, p34
- ISSN
1300-7777
- Publication type
Article
- DOI
10.5505/tjh.2012.29795