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- Title
Effect of chloroprocaine combined with morphine on analgesia, adverse reactions and dynamic changes in inflammation in patients receiving TURP.
- Authors
Lin Zhu; Peili Lin; Xulei Lv; Jingyu Zhao; Mengmeng Li
- Abstract
Purpose: To investigate the influence of chloroprocaine combined with morphine on the analgesic effects, adverse reactions and inflammation factors in patients receiving transurethral resection of the prostate (TURP). Methods: A total of 80 patients with benign prostatic hyperplasia (BPH) in the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China, were divided into morphine group and combination-therapy group (morphine combined with chloroprocaine). Pain index, changes in inflammatory factors and incidence of adverse reactions in the two groups of patients were assessed. Results: The morphine group and combination-therapy group showed basic profile prior to the treatments. Visual Analogue Scale (VAS) scores before operation and 6 h after operation in the morphine group were similar to those in the combination-therapy group, but the scores at 12, 24 and 48 h after operation in the combination-therapy group were significantly lower than those in the morphine group. Similarly, the combination-therapy group showed lower levels of substance P (SP) and bradykinin (BK) at 12, 24 and 48 h after operation than the morphine group (p < 0.05). Both groups exhibited similar levels of serum inflammatory factors before the operation, but the levels decreased in the combination-therapy group when compared with those in the morphine group after operation (p < 0.05). The combination-therapy group also showed a lower incidence of adverse reactions than the morphine group. Conclusion: Chloroprocaine combined with morphine effectively ameliorates postoperative pain, lowers secretion of tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10), and decreases the incidence of postoperative adverse reactions, thus affording a high level of safety after operation.
- Subjects
BEIJING (China); CHINA; TUMOR necrosis factors; TRANSURETHRAL prostatectomy; BENIGN prostatic hyperplasia; MORPHINE; SUBSTANCE P
- Publication
Tropical Journal of Pharmaceutical Research, 2022, Vol 21, Issue 4, p893
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v21i4.29