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- Title
A Role for AnkyrinG in Maturation and Maintenance of the Nodes of Ranvier.
- Authors
Yang, Benjamin; Curran, Bridget M.; Tymanskyj, Stephen R.
- Abstract
The article offers information on cytoskeletal protein AnkyrinG (AnkG) helps in maturation and maintenance of the nodes of Ranvier in central nervous system and peripheral nervous system. Topics discussed include knocking out AnkG in sensory neurons by administration of tamoxifen in mice; eliminate the clustering of βIV spectrin at nodes; and without AnkG tight spatial localization of proteins and their interactions disrupted with each other which leads to neuron degeneration.
- Subjects
ANKYRINS; NODES of Ranvier; CENTRAL nervous system; PERIPHERAL nervous system; SENSORY neurons; TAMOXIFEN
- Publication
Journal of Neuroscience, 2017, Vol 37, Issue 24, p5796
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0858-17.2017