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- Title
Oncomodulin, an EF-Hand Ca<sup>2+</sup> Buffer, Is Critical for Maintaining Cochlear Function in Mice.
- Authors
Tong, Benton; Hornak, Aubrey J.; Maison, Stéphane F.; Ohlemiller, Kevin K.; Liberman, M. Charles; Simmons, Dwayne D.
- Abstract
Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.
- Subjects
ONCOMODULIN; COCHLEA; COCHLEA physiology; CALCIUM channels; HAIR cells; BRAIN stem; LABORATORY mice; DISEASES
- Publication
Journal of Neuroscience, 2016, Vol 36, Issue 5, p1631
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3311-15.2016