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- Title
Family History of Diabetes Mellitus Determines Insulin Sensitivity and β Cell Function in Polycystic Ovary Syndrome.
- Authors
Vrbíková, J.; Grimmichová, T.; Dvoŕáková, K; Hill, M.; Stanická, S.; Vondra, K.
- Abstract
Objective: To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM 2 (FH+) were examined using euglycemic hyperinsulinemic clamp and an arginine secretion test (insulin and glucagon at fasting glycemia (AIRFG and AGRFG) and at hyperglycemia (AIR14 and AGR14)). FH+ women were more insulin resistant than FH- with lower insulin sensitivity index corrected per lean body mass (p<0.05). They had significantly higher triglycerides (p<0.05) and lower HDL-cholesterol (p<0.05) than C or FH- women. Concerning insulin secretion, AIRFG was increased in FH+ women comparing FH- women (p<0.05). Disposition indices derived from AIRFG or AIR14 and insulin sensitivity index did not differ between FH+ or FH-. Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion.
- Subjects
DIABETES; POLYCYSTIC ovary syndrome; INSULIN resistance; TRIGLYCERIDES; DISEASES in women; WOMEN'S health; GENETIC disorders; GENEALOGY
- Publication
Physiological Research, 2008, Vol 57, Issue 4, p547
- ISSN
0862-8408
- Publication type
Article