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- Title
Management of luspatercept therapy in patients with transfusion‐dependent β‐thalassaemia.
- Authors
Sheth, Sujit; Taher, Ali T.; Coates, Thomas D.; Kattamis, Antonis; Cappellini, Maria Domenica
- Abstract
Summary: Patients with transfusion‐dependent β‐thalassaemia require lifelong, regular red blood cell transfusions for survival; however, frequent blood transfusions are associated with an increased risk of iron overload, transfusion‐transmitted disease and alloimmunization, as well as reduced quality of life. Luspatercept, an erythroid maturation agent that promotes late‐stage erythroid maturation independently of erythropoietin, has demonstrated efficacy in reducing transfusion burden in patients with transfusion‐dependent β‐thalassaemia. In this review, we discuss treatment initiation, ongoing evaluation, dose adjustment and management of adverse events in transfusion‐dependent patients with β‐thalassaemia receiving luspatercept, and we provide guidance on how to determine whether patients are deriving clinical benefit.
- Subjects
ALLOIMMUNITY; ERYTHROPOIETIN receptors; BLOOD transfusion reaction; RED blood cell transfusion; ADVERSE health care events; IRON overload; BLOOD transfusion
- Publication
British Journal of Haematology, 2023, Vol 201, Issue 5, p824
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18801