We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bone marrow biopsies do not impact response assessment for follicular lymphoma patients treated on clinical trials.
- Authors
Rutherford, Sarah C.; Li, Valery; Ghione, Paola; Chen, Zhengming; Martin, Peter; Leonard, John P.
- Abstract
Clinical trials enrolling follicular lymphoma ( FL) patients typically require bone marrow biopsies ( BMBs) at baseline and at a subsequent point if complete response is achieved. These procedures are painful, take time and add cost. We hypothesized that BMBs do not provide information significant for response assessment in most follicular lymphoma patients on clinical trials. We identified 99 patients treated on clinical trials for follicular lymphoma between 2000 and 2016. BMBs resulted in a possible response assessment change in 1·0% of patients (95% confidence interval: 0·0-5·5%). We conclude that mandatory BMBs at baseline and for response assessment are unnecessary in clinical trials for follicular lymphoma.
- Subjects
BONE biopsy; LYMPHOMAS; BIOPSY; CLINICAL trials; MEDICAL experimentation on humans
- Publication
British Journal of Haematology, 2017, Vol 179, Issue 2, p242
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.14839