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- Title
Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells.
- Authors
Han, Ah-Reum; Lee, Sanghun; Han, Sujin; Lee, Yeon Jin; Kim, Jin-Baek; Seo, Eun Kyoung; Jung, Chan-Hun
- Abstract
Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3). These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations. These results suggest that triterpenoids 1–3 isolated from C. asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.
- Subjects
CELL physiology; CELL motility; ETHANOL; HYDROCARBONS; LEAVES; LUNG tumors; MEDICINAL plants; METASTASIS; MOLECULAR structure; RADIATION; PLANT extracts; TREATMENT effectiveness; PHYSIOLOGICAL effects of radiation
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2020, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2020/3683460