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- Title
Oxaliplatin-induced acute thrombocytopenia.
- Authors
Erdem, Gokmen Umut; Dogan, Mutlu; Demirci, Nebi Serkan; Zengin, Nurullah
- Abstract
Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are neurotoxicity (peripheral neuropathy), myelosuppression with moderate thrombocytopenia and gastrointestinal toxicity (diarrhea). Thrombocytopenia might be related to myelosuppression and/or drug-induced immune thrombocytopenia (DIIT). In here, oxaliplatin-induced thrombocytopenia is discussed with review of the literature.
- Subjects
THROMBOCYTOPENIA treatment; OXALIPLATIN; DNA damage; PERIPHERAL neuropathy; MYELOSUPPRESSION; ANTINEOPLASTIC agents; ORGANOPLATINUM compounds; GASTROINTESTINAL tumors; THROMBOCYTOPENIA; DISEASE complications; DIAGNOSIS
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 2, p509
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.154056