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- Title
Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer.
- Authors
Wei-Dong Zhang; He-Xin Chen; Yun-Xia Wang; Zhi-Ping Chen; Zhong-Jie Shan; Guang Xu; Zhang, Wei-Dong; Chen, He-Xin; Wang, Yun-Xia; Chen, Zhi-Ping; Shan, Zhong-Jie; Xu, Guang
- Abstract
<bold>Aim Of Study: </bold>The aim was to explore the structure and functions of new target spot c-Myc target from laryngeal cancer cell. (MTLC) of c-Myc gene.<bold>Methods: </bold>This study adopted bioinformatic methods to analyze the physicochemical property, secondary structure, hydrophobic region, a transmembrane region, and prediction of functions.<bold>Results: </bold>The results showed that the whole length of the open reading frames was 708 bp, coding was 235 amino acids. This protein was a basic protein possessed two transmembrane structures and weight was about 26592.5 Da. The main elements of secondary structure were alpha-helix and random coil. MTLC was a membrane constitutive protein that possessed signal transduction and regulation may locate on karyotheca as results of subcellular localization and function prediction.<bold>Conclusion: </bold>This study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer.
- Subjects
BIOINFORMATICS; LARYNGEAL cancer patients; CANCER cells; LARYNGEAL cancer; AMINO acids; PROTEIN metabolism; PHYSICAL &; theoretical chemistry; LARYNX; LARYNGEAL tumors; PROTEINS; NUCLEAR proteins
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 1, p58
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.146083