We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of Gonadotropin α, Follicle-stimulating Hormone β, and Luteinizing Hormone β Genes of the Hermaphroditic Fish Kryptolebias marmoratus Exposed to Octylphenol, 17β Estradiol, and Tamoxifen.
- Authors
Rhee, Jae‐Sung; Lee, Young‐Mi; Seo, Jung Soo; Han, JeongHoon; Lee, Jae‐Seong
- Abstract
In order to study the expression of the gonadotropin α subunit and β subunit [follicle-stimulating hormone (FSH)-β and luteinizing hormone (LH)-β] cDNAs in the hermaphroditic fish Kryptolebias marmoratus, we cloned these genes and analyzed their modulatory effects in the brain/pituitary tissue after exposure to 17β estradiol (E2), tamoxifen (TMX), and octyphenol. Gonadotropin β subunit (FSH-β and LH-β) showed E2-dependent upregulation in most hermaphrodites, whereas TMX did not show elevated expression. Octyphenol also showed a similar effect of upregulation on FSH-β expression but not for the LH-β gene. These results suggest that the expression of FSH-β and LH-β in K. marmoratus is associated with their expression on endocrine-disrupting chemicals in this species.
- Subjects
GENE expression; LUTEINIZING hormone releasing hormone; GONADOTROPIN; FOLLICLE-stimulating hormone; INTERSEXUALITY in animals; MANGROVE rivulus; ESTRADIOL; TAMOXIFEN; ENDOCRINOLOGY
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1163, p508
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2009.04450.x