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- Title
G Protein–Coupled Receptor Structures, Molecular Associations, and Modes of Regulation.
- Authors
Miller, Laurence J.
- Abstract
G protein–coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.
- Subjects
G proteins; OLIGOMERS; POLYMERIZATION; LIGAND binding (Biochemistry); ALLOSTERIC regulation; PHYSIOLOGICAL control systems; DRUG activation; TARGETED drug delivery; MOLECULAR structure
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1144, p1
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1418.000