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- Title
The Predictive Value and Evolution of N-Terminal Pro-B-Type Natriuretic Peptide Levels Following Transcutaneous Aortic Valve Implantation.
- Authors
SPARGIAS, KONSTANTINOS; POLYMEROS, SPYROS; DIMOPOULOS, ANTONIS; MANGINAS, ATHANASSIOS; PAVLIDES, GREGORY; BALANIKA, MARINA; SMIRLI, ANNA; STAVRIDIS, GEORGE; DANGAS, GEORGE; COKKINOS, DENNIS V.
- Abstract
Aims: We sought to define the predictive value and evolution of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels following transcutaneous aortic valve implantation (TAVI). Methods and Results: We investigated 91 consecutive patients who underwent TAVI (59 transfemoral [TF], 32 transapical [TA]) in our institution. The balloon-expandable valve was implanted in 75 and the self-expanding in 16 patients. The baseline (within 48 hours prior to procedure), early (24-74 hours), and late (3-12 months) postprocedural NT-proBNP levels were determined. The mortality status of all patients was ascertained as of September 2010. The 30-day and 1.3(mean)-year mortality was 3% and 12% (2%, 9% in the TF and 6%, 19% in the TA group). Increased baseline (χ2= 5.9, P = 0.016) and early (χ2= 4.9, P = 0.028) NT-proBNP levels were predictive of mortality. All decrements of the NT-proBNP levels in the TF patients were significant (baseline 4,984 ± 8,106 vs. early 3,912 ± 6,551 pg/mL, P = 0.016; late 633 ± 606 pg/mL, P = 0.003). In contrast, there was a trend for the early levels to increase in the TA patients (6,423 ± 8,897 vs. 8,100 ± 10,178 pg/mL, P = 0.090), and a significant decline in the late levels as compared to baseline (1,704 ± 3,417 pg/mL, P = 0.005). Conclusion: NT-proBNP levels are predictive of mortality following TAVI. There is a differential early evolution of their levels between the TF and TA patients and a significant decline later in both groups. (J Interven Cardiol 2011;24:462-469)
- Subjects
ATRIAL natriuretic peptides; AORTIC valve; MORTALITY; AORTIC stenosis treatment; ECHOCARDIOGRAPHY
- Publication
Journal of Interventional Cardiology, 2011, Vol 24, Issue 5, p462
- ISSN
0896-4327
- Publication type
Article
- DOI
10.1111/j.1540-8183.2011.00654.x