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- Title
Intratumor distribution and test-retest comparisons of physiological parameters quantified by dynamic contrast-enhanced MRI in rat U251 glioma.
- Authors
Aryal, Madhava P.; Nagaraja, Tavarekere N.; Brown, Stephen L.; Lu, Mei; Bagher‐Ebadian, Hassan; Ding, Guangliang; Panda, Swayamprava; Keenan, Kelly; Cabral, Glauber; Mikkelsen, Tom; Ewing, James R.
- Abstract
The distribution of dynamic contrast-enhanced MRI (DCE-MRI) parametric estimates in a rat U251 glioma model was analyzed. Using Magnevist as contrast agent (CA), 17 nude rats implanted with U251 cerebral glioma were studied by DCE-MRI twice in a 24 h interval. A data-driven analysis selected one of three models to estimate either (1) plasma volume ( vp), (2) vp and forward volume transfer constant ( Ktrans) or (3) vp, Ktrans and interstitial volume fraction ( ve), constituting Models 1, 2 and 3, respectively. CA distribution volume ( VD) was estimated in Model 3 regions by Logan plots. Regions of interest (ROIs) were selected by model. In the Model 3 ROI, descriptors of parameter distributions - mean, median, variance and skewness - were calculated and compared between the two time points for repeatability. All distributions of parametric estimates in Model 3 ROIs were positively skewed. Test-retest differences between population summaries for any parameter were not significant ( p ≥ 0.10; Wilcoxon signed-rank and paired t tests). These and similar measures of parametric distribution and test-retest variance from other tumor models can be used to inform the choice of biomarkers that best summarize tumor status and treatment effects. Copyright © 2014 John Wiley & Sons, Ltd.
- Publication
NMR in Biomedicine, 2014, Vol 27, Issue 10, p1230
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.3178