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- Title
Comparison of dual to single contrast bolus magnetic resonance myocardial perfusion imaging for detection of significant coronary artery disease.
- Authors
Groothuis, Jan G.J.; Kremers, Frans P.P.J.; Beek, Aernout M.; Brinckman, Stijn L.; Tuinenburg, Alvin C.; Jerosch-Herold, Michael; van Rossum, Albert C.; Hofman, Mark B.M.
- Abstract
Purpose: To investigate the incremental diagnostic value of dual-bolus over single-contrast-bolus first pass magnetic resonance myocardial perfusion imaging (MR-MPI) for detection of significant coronary artery disease (CAD). Materials and Methods: Patients (n = 49) with suspected CAD underwent first pass adenosine stress and rest MR-MPI and invasive coronary angiography (CA). Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was injected with a prebolus (1 mL) and a large bolus (0.1 mmol/kg). For the single-bolus technique, the arterial input function (AIF) was obtained from the large-contrast bolus. For the dual-bolus technique, the AIF was reconstructed from the prebolus. Absolute myocardial perfusion was calculated by Fermi-model constrained deconvolution. Receiver operating characteristic (ROC) analysis was used to investigate diagnostic accuracy of MR myocardial perfusion imaging for detection of significant CAD on CA at vessel-based analysis. Results: The area under the curve (AUC) of the minimal stress perfusion value for the detection of significant CAD using the single-bolus and dual-bolus technique was 0.85 ± 0.04 (95% confidence interval [CI], 0.77-0.93) and 0.77 ± 0.05 (95% CI, 0.67-0.86), respectively. Conclusion: In this study the dual-bolus technique had no incremental diagnostic value over single-bolus technique for detection of significant CAD with the used contrast concentrations. J. Magn. Reson. Imaging 2010;32:88-93. © 2010 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2010, Vol 32, Issue 1, p88
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22231