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- Title
Diagnosis of Head and Neck Precancerous Lesions in an Animal Model Using Fluorescence Spectroscopy.
- Authors
Dhingra, Jagdish K.; Zhang, Xia; McMillan, Kathleen; Kabani, Sadru; Manoharan, Ramasamy; Itzkan, Irving; Feld, Michael S.; Shapshay, Stanley M.
- Abstract
Laser-induced fluorescence (LIF) of tissues depends on their biochemical and histomorphologic characteristics. LIF spectroscopic properties of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced precancerous and early cancerous lesions in a hamster buccal pouch mucosa model were studied. Fluorescence spectra from neoplastic lesions showed a characteristic fluorescence peak in the red region of the visible spectrum centered between 630 and 640 nm when excited with 410-nm light. Using this as a diagnostic criterion, 45 of 49 lesions studied were correctly diagnosed, including early dysplastic lesions. Follow-up study of four dysplastic lesions over 2 weeks revealed an increase in red fluorescence intensity. The findings of these experiments suggest that LIF spectroscopy may be a valuable noninvasive technique not only for early diagnosis of head and neck cancer, but also to probe a possible biochemical surrogate biomarker in the follow-up of suspected lesions.
- Publication
Laryngoscope, 1998, Vol 108, Issue 4, p471
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1097/00005537-199804000-00002