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- Title
Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds.
- Authors
Kandinska, Meglena I.; Burdzhiev, Nikola T.; Cheshmedzhieva, Diana V.; Ilieva, Sonia V.; Grozdanov, Peter P.; Vilhelmova-Ilieva, Neli; Nikolova, Nadya; Lozanova, Vesela V.; Nikolova, Ivanka
- Abstract
A series of novel 1-oxo-2,3,4-trisubstituted tetrahydroisoquinoline (THIQ) derivatives bearing other heterocyclic moieties in their structure were synthesized based on the reaction between homophthalic anhydride and imines. Initial studies were carried out to establish the anti-coronavirus activity of some of the newly obtained THIQ-derivatives against two strains of human coronavirus-229E and OC-43. Their antiviral activity was compared with that of their close analogues, piperidinones and thiomorpholinones, previously synthesized in our group, with aim to expand the range of the tested representative sample and to obtain valuable preliminary information about biological properties of a wider variety of compounds.
- Subjects
MOIETIES (Chemistry); TETRAHYDROISOQUINOLINES; PIPERIDONES; COMPARATIVE studies; IMINES
- Publication
Molecules, 2023, Vol 28, Issue 3, p1495
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28031495