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- Title
Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N -Formylation of Amines with Triethyl Orthoformate.
- Authors
Salami, Sodeeq Aderotimi; Siwe-Noundou, Xavier; Krause, Rui W. M.
- Abstract
In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4–SiO2). All reactions were performed in refluxing triethyl orthoformate (65 °C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.
- Subjects
SILICA gel; FORMYLATION; AMINES; ORGANIC synthesis; CATALYSTS recycling; SULFURIC acid
- Publication
Molecules, 2022, Vol 27, Issue 13, p4213
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27134213