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- Title
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II.
- Authors
Van Rijn, Richard M.; Spetea, Mariana
- Abstract
The high affinity and selectivity for OR over µOR and OR make these valuable tools, which could, for example, be used to investigate the utility of this class of OR modulators in treating Alzheimers' disease. A few neurotransmitter systems have fascinated the research community, as much as the opioid system (i.e., opioid ligands and their receptors). Cellular assays indicate that the molecule has a 10-fold preference for binding to the OR over µ- and -opioid receptors (µOR and OR, respectively), and it competes with orthosteric ligands. The final collection of articles in this Special issue covers a broad area of opioid research that encompass all four opioid receptors; in silico, in vitro, and in vivo approaches; and small molecules and peptide ligand design.
- Subjects
OPIOID receptors; DRUG discovery; MOLECULAR dynamics; OPIOIDS; BIOSYNTHESIS; SMALL molecules
- Publication
Molecules, 2022, Vol 27, Issue 10, p3140
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27103140