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- Title
Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies.
- Authors
Honing, Maarten; Martini, Chris; van Velzen, Monique; Niesters, Marieke; Dahan, Albert; Boon, Martijn
- Abstract
General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.
- Subjects
PHARMACOLOGY; CAROTID body; MUSCLE relaxants; ANESTHETICS; LOSS of consciousness; ANALGESIA; REFLEXES; MUSCARINIC receptors
- Publication
Molecules, 2020, Vol 25, Issue 24, p5974
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25245974