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- Title
Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies.
- Authors
Lemnaru (Popa), Georgiana-Mădălina; Truşcă, Roxana Doina; Ilie, Cornelia-Ioana; Țiplea, Roxana Elena; Ficai, Denisa; Oprea, Ovidiu; Stoica-Guzun, Anicuța; Ficai, Anton; Dițu, Lia-Mara; Martin, Patrick M.; Fanani, Maria Laura; Joly, Nicolas
- Abstract
The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings' wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing's property. The results confirmed the drugs' presence in the bacterial-cellulose dressing's structure as well as the antimicrobial efficiency against Staphylococcus aureus and Escherichia coli. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.
- Subjects
BACITRACIN; AMOXICILLIN; CELLULOSE; ANTIBACTERIAL agents; STAPHYLOCOCCUS aureus; THERMAL analysis
- Publication
Molecules, 2020, Vol 25, Issue 18, p4069
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25184069