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- Title
Efficient Suzuki–Miyaura C-C Cross-Couplings Induced by Novel Heterodinuclear Pd-bpydc-Ln Scaffolds.
- Authors
Ding, Fu; Li, Yanli; Yan, Pingxuan; Deng, Yan; Wang, Dongping; Zhang, Yajing; Dragutan, Ileana; Dragutan, Valerian; Wang, Kangjun
- Abstract
An easy access to a series of previously unreported heterodinuclear Pd-Ln compounds, Pd-bpydc-La, Pd-bpydc-Ce and Pd-bpydc-Nd (bpydc = 2,2′-bipyridine-5,5′-dicarboxylate) has been developed. The Pd-Ln hybrid networks were effectively applied as catalysts in Suzuki–Miyaura C-C cross-coupling reactions of 4-bromoanisole and 4-bromobenzonitrile with phenylboronic acid, under mild conditions. A systematic investigation revealed Pd-bpydc-Nd as the most active catalyst. In all cases, reaction yields varied with the base, catalyst loading and substantially augmented with temperature (from 30 to 60 °C). Substituent effects were operative when changing from 4-bromoanisole to 4-bromobenzonitrile. The key role played by the lanthanides, aromatic substrate and base, in modulating the Pd-catalytic cycle has been highlighted. Importantly, the new catalysts proved to be stable in air and vs. functionalities and are quite efficient in Suzuki–Miyaura carbon-carbon bond formation conducted in protic solvents.
- Subjects
SUZUKI reaction; CATALYSTS; RARE earth metals; AROMATIC compounds; CARBON-carbon bonds
- Publication
Molecules, 2018, Vol 23, Issue 10, p2435
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23102435