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- Title
Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum.
- Authors
Torres-Mendoza, Daniel; Coronado, Lorena M.; Pineda, Laura M.; Guzmán, Héctor M.; Dorrestein, Pieter C.; Spadafora, Carmenza; Gutiérrez, Marcelino
- Abstract
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.
- Subjects
PLASMODIUM falciparum; PLASMODIUM; ANALYTICAL chemistry; BACILLUS (Bacteria); BACILLACEAE
- Publication
Molecules, 2018, Vol 23, Issue 9, p2179
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23092179