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- Title
Insights into Animal and Plant Lectins with Antimicrobial Activities.
- Authors
de Oliveira Dias, Renata; dos Santos Machado, Leandro; Migliolo, Ludovico; Franco, Octavio Luiz
- Abstract
Lectins are multivalent proteins with the ability to recognize and bind diverse carbohydrate structures. The glyco -binding and diverse molecular structures observed in these protein classes make them a large and heterogeneous group with a wide range of biological activities in microorganisms, animals and plants. Lectins from plants and animals are commonly used in direct defense against pathogens and in immune regulation. This review focuses on sources of animal and plant lectins, describing their functional classification and tridimensional structures, relating these properties with biotechnological purposes, including antimicrobial activities. In summary, this work focuses on structural-functional elucidation of diverse lectin groups, shedding some light on host-pathogen interactions; it also examines their emergence as biotechnological tools through gene manipulation and development of new drugs.
- Subjects
LECTINS; ANTI-infective agents; CARBOHYDRATES; PLANT protein structure; HOST-parasite relationships; DRUG development
- Publication
Molecules, 2015, Vol 20, Issue 1, p519
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20010519