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- Title
Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro.
- Authors
Zhi-Jun Dai; Bao-Feng Wang; Wang-Feng Lu; Zhi-Dong Wang; Xiao-Bin Ma; Wei-Li Min; Hua-Feng Kang; Xi-Jing Wang; Wen-Ying Wu
- Abstract
Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.
- Subjects
METASTASIS; CANCER-related mortality; SCUTELLARIA; FLAVONOIDS; CELL lines; MESSENGER RNA
- Publication
Molecules, 2013, Vol 18, Issue 1, p934
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18010934