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- Title
Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata.
- Authors
Chia-Chun Yu; Ching-Ruey Hsieh; George Hsiao; Pi-Yu Chen; Meng-Lun Chang; Hwa-Wen Yin; Tzong-Huei Lee; Ching-Kuo Lee
- Abstract
Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5α,8,9α,10α,12)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
- Subjects
EUPHORBIA; ABIETANE; CELL lines; BIOLOGICAL models; CHEMICAL structure
- Publication
Molecules, 2012, Vol 17, Issue 2, p2082
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17022082