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- Title
Molecular characterization of three ferret badger ( Melogale moschata) rabies virus isolates from Jiangxi province, China.
- Authors
Zhao, Jinghui; Liu, Ye; Zhang, Shoufeng; Zhang, Fei; Wang, Ying; Mi, Lijuan; Wang, Shuchao; Hu, Rongliang
- Abstract
Ferret badger (FB) rabies viruses JX09-17(fb), JX09-18 and JX10-37 were isolated from three different regions in Jiangxi province, China, in 2009 and 2010. The complete nucleotide sequence identity between these three isolates was 87-93 %. Compared with the other Chinese rabies virus isolates and vaccine strains, 101 substitutions (53 in JX10-37, 23 in JX09-17(fb) and 25 in JX09-18) in the five structural proteins were observed, and 47 of these substitutions (27 in JX10-37, 14 in JX09-17(fb) and 6 in JX09-18) were unique among lyssaviruses. Amino acid substitutions of S and Q were noted respectively in the G protein antigenic site I of JX10-37 and site III in JX09-17(fb). Phylogenetic analysis showed that JX09-17(fb) is rooted within the China I lineage, JX09-18 is in China II, and JX10-37 is independent. Evolutionary analysis and comparative sequence data indicate that isolate JX10-37 is a variant virus that diverged from canine rabies viruses around 1933 (range 1886-1963).
- Subjects
JIANGXI Sheng (China); MOLECULAR virology; RABIES virus; NUCLEOTIDE sequence; RABIES vaccines; CYTOSKELETAL proteins; VIRUS phylogeny
- Publication
Archives of Virology, 2014, Vol 159, Issue 8, p2059
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-014-2044-0