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- Title
No Correlation between A(-1438)G Polymorphism in 5-HT2A Receptor Gene Promoter and the Density of Frontal Cortical 5-HT2A Receptors in Schizophrenia.
- Authors
Kouzmenko, Alexander P.; Scaffidi, Antonietta; Pereira, Avril M.; Hayes, Wendy L.; Copolov, David L.; Dean, Brian
- Abstract
The A(-1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was studied using brain tissue donated at autopsy from 58 schizophrenic and 64 non-schizophrenic subjects. A linkage between genotypes for the A(-1438)G and a T102C polymorphic site identified in a previous study was observed. Our data suggest no association of the A(-1438)G polymorphism with schizophrenia and no effect of the promoter genotype upon 5-HT2AR densities in either the schizophrenic or non-schizophrenic groups.
- Publication
Human Heredity, 1999, Vol 49, Issue 2, p103
- ISSN
0001-5652
- Publication type
Article
- DOI
10.1159/000022853