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- Title
Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol.
- Authors
Shchulkin, A. V.; Mylnikov, P. Yu.; Chernykh, I. V.; Esenina, A. S.; Yakusheva, E. N.
- Abstract
The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and liver was measured by HPLC-MS/MS. After single intravenous administration of Mexidol, succinate was evenly distributed in organs and tissues and quickly eliminated from the body. The pharmacokinetics of succinate was described by a two-chamber model. An increase in the level of succinate in the cytoplasmic fraction of the liver, myocardium, and cerebral cortex cells and a minor increase in the mitochondrial fraction were observed. The maximum increase in the level of succinate in the cytoplasmic fraction was observed in the liver tissue, a less pronounced elevation was observed in the cerebral cortex and myocardium; no significant differences between the cerebral cortex and myocardium were observed by this parameter.
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 175, Issue 1, p54
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05810-5