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- Title
Phenotypic Features of Mesenchymal Stem Cell Subpopulations Obtained under the Influence of Various Toll-Like Receptors Ligands.
- Authors
Shoshina, O. O.; Kozhin, P. M.; Shadrin, V. S.; Romashin, D. D.; Rusanov, A. L.; Luzgina, N. G.
- Abstract
The paper characterizes phenotypic features of subpopulations of human adipose tissue mesenchymal stem cells (MSC) resulting from exposure to Toll-like receptors ligands. MSC1 and MSC2 phenotypes were induced by exposure to LPS and polyinosinic-polycytidylic acid, respectively. Different exposures to Toll-like receptors ligands, short-term (3 h) and long-term (24 h), were studied. The cytokine profile of cells with the MSC2 phenotype differed depending on the duration of exposure to the inductor, while the cytokine profile of cells with the MSC1 phenotype remained stable. Morphometric features of mesenchymal stem cells with the MSC1 and MSC2 phenotypes, as well as differences in the IDO gene expression were identified. These differences can be used to distinguish between these cell types.
- Subjects
MESENCHYMAL stem cells; PHENOTYPES; TOLL-like receptors; LIGANDS (Biochemistry); CYTOKINES; ADIPOSE tissues
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 4, p555
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05105-7