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- Title
Design of Chemical Conjugate for Targeted Therapy of Multiple Sclerosis Based of Constant Fragment of Human Antibody Heavy Chain and Peptoid Analog of Autoantigen MOG.
- Authors
Lomakin, Y.; Stepanov, A.; Balabashin, D.; Ponomarenko, N.; Smirnov, I.; Belogurov, A.
- Abstract
Elimination of B cells producing autoantibodies to neuroantigens is considered as beneficial in the treatment of multiple sclerosis. Myelin oligodendrocyte glycoprotein (MOG) is a significant autoantigen in multiple sclerosis. It was shown that MOG-like peptoid AMogP3 can bind autoantibodies produced by pathological lymphocytes. We propose a structure of an innovative drug for targeted elimination of the pool of autoreactive B cells responsible for multiple sclerosis pathogenesis; this compound is a complex of peptoid AMogP3 with Fc fragment of human immunoglobulin. The obtained Fc-PEG-AMogP3 conjugate effectively interact with autoreactive antibodies, which attests to their high therapeutic potential.
- Subjects
MULTIPLE sclerosis treatment; IMMUNOGLOBULINS; AUTOANTIGENS; B cells; GLYCOPROTEINS
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 6, p777
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3711-4