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- Title
Studying the Photoprotective Activity of a New Class of Heteroaromatic Antioxidants.
- Authors
N. Sakina; A. Golubkov; L. Smirnov; M. Ostrovsky; A. Dontsov
- Abstract
Photoprotective activity of heteroaromatic compounds (derivatives of 3-hydroxypyridine, amino-6-hydroxybenzothiazole, and 5-hydroxybenzimidazole) was studied in the system of UV-induced cardiolipin peroxidation. Although all three compounds had the antioxidant effect during free radical oxidation of luminol, only derivatives of amino-6-hydroxybenzothiazole and 5-hydroxybenzimidazole inhibited the process of UV-induced lipid peroxidation. The 3-hydroxypyridine derivative did not inhibit UV-induced cardiolipin peroxidation, which was probably related to degradation of this compound under the influence of UV light and formation of degradation products that cannot inhibit free radical processes.
- Subjects
AROMATIC compounds; ANTIOXIDANTS; PHYSIOLOGICAL effects of ultraviolet radiation; CARDIOLIPIN; PEROXIDATION; FREE radical pathophysiology; PHOTOCHEMISTRY; PREVENTION; THERAPEUTICS
- Publication
Bulletin of Experimental Biology & Medicine, 2009, Vol 147, Issue 2, p193
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-009-0472-8