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- Title
Exploring the causes of semen quality changes post-bariatric surgery: a focus on endocrine-disrupting chemicals.
- Authors
Magalhaes, Danielly P; Mahalingaiah, Shruthi; Perry, Melissa J
- Abstract
Rapid weight loss promoted by bariatric surgery (BS) can release accumulated lipophilic endocrine-disrupting chemicals (EDCs), making these chemicals systemically available. Men typically have a higher EDC body burden and lose more weight post-BS than women, which may put male BS patients at high risk for testicular toxicity. In this review, we analyze the impacts of BS on semen parameters with a particular focus on the potential effects of EDCs. After BS, serum EDC concentrations progressively increase; and there is evidence that semen parameters deteriorate after BS. Although elevated serum EDC concentrations are associated with inferior sperm parameters, links between semen parameters and EDCs post-BS have not been studied. Understanding these potential associations requires adequately powered studies, particularly within prospective longitudinal cohorts with long-term follow-up for sperm parameters, nutritional status, sex-hormones levels and serum EDC concentrations. Studying BS patients prospectively provides the important opportunity to evaluate dose-response effects of EDC serum concentrations on sperm quality and function. Research is also needed to identify critical chemical exposure periods post-BS to inform reproductive decisions, including consideration of sperm preservation before surgery.
- Subjects
SEMEN analysis; ENDOCRINE disruptors; WEIGHT loss; BODY burden; PERSISTENT pollutants; FERTILITY preservation; FEMALE condoms; POLLUTANTS; BARIATRIC surgery; SEMEN; LONGITUDINAL method
- Publication
Human Reproduction, 2022, Vol 37, Issue 5, p902
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/deac039