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- Title
Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis.
- Authors
Po-Chin Huang; Eing-Mei Tsai; Wan-Fen Li; Pao-Chi Liao; Meng-Chu Chung; Ya-Hui Wang; Shu-Li Wang
- Abstract
BACKGROUND: Phthalates are known to have estrogenic effects in cell models and experimental animals. However, the evidence regarding the effects of phthalates on human reproduction is still limited. We conducted a case–control study to determine whether estrogen-dependent diseases are associated with phthalate exposure and how the glutathione S-transferase M1 (GSTM1; a major detoxification enzyme) genotype modulates the risk.
- Subjects
PHTHALATE esters; GLUTATHIONE transferase; GENETIC polymorphisms; ENDOMETRIOSIS; SMOOTH muscle tumors
- Publication
Human Reproduction, 2010, Vol 25, Issue 4, p986
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deq015